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Vitamin C as Calcium Ascorbate with additional antioxidants
DESCRIPTION
Ester-C? Plus capsules, provided by Douglas Laboratories?, contain a non-acidic, calcium ascorbate form of vitamin C combined with potent antioxidants to support the healthy functioning of the entire body.
Ester-C? is a unique form of vitamin C that is created through a patented, water-based process that combines vitamin C and calcium. Ester-C is non-acidic and should be well-tolerated by those who are sensitive to the acidic nature of ascorbic acid.
FUNCTIONS
Vitamin C (ascorbic acid) has numerous biological functions. It is essential for the synthesis of collagen and glycosaminoglycans, which are the building materials of all connective tissues, such as skin, blood vessels, tendons, joint cartilage and bone. Vitamin C is the required coenzyme for two groups of enzymes that catalyze the crosslinking of collagen fibers - lysyl hydroxylases and prolyl hydroxylases. As such, vitamin C is essential for normal wound healing and capillary health.
Vitamin C participates in the biosynthesis of carnitine, serotonin, and certain neurotransmitters, including norepinephrine.
Vitamin C is among the most powerful antioxidants in humans and animals. It is a water-soluble, chain-breaking antioxidant that reacts directly with superoxide, hydroxyl radicals, and singlet oxygen. Laboratory studies show that vitamin C completely protects lipids in plasma and low-density lipoprotein (LDL) against peroxidative damage. In addition, vitamin C interacts with glutathione and alpha-lipoic acid, and regenerates vitamin E.
The antioxidant functions of vitamin C appear to have clinical significance in providing protection from free radical damage to the eyes, lungs, blood and the immune system.
Bioflavonoids (also called flavonoids) are a class of phytochemicals that are potent antioxidants, which scavenge many potentially damaging free radicals. Another aspect of the antioxidant properties of bioflavonoids is their synergy with vitamin C. The bitter tasting flavanones hesperidin and naringin, from the white albedo layer of citrus peels, have been shown to extend the nutritional functions of vitamin C.
Bioflavonoids are also capable of binding to metal ions, which prevents these metals from acting as catalysts in the body to enhance free radical production.
Many bioflavonoids, especially rutin and quercetin, support the health of the body's circulatory system by helping maintain capillary blood flow and proper vascular permeability, integrity, and resiliency.
Pycnogenol? is made exclusively from the bark of the European coastal pine, Pinus maritima, which grows along the Atlantic coast of southern France. Pycnogenol is one of the most powerful natural free-radical scavengers yet discovered. As such, it reduces oxidative damage to vital tissues and helps maintain a healthy capillary system.
INDICATIONS
Ester-C? Plus may be a useful dietary supplement for those who wish to supplement their diet with this complementary blend of a unique, non-acidic form of vitamin C and citrus bioflavonoids.
FORMULA (#7847)
Each capsule contains:
Vitamin C .................................................. 540 mg
(from 675 mg of Ester-C? calcium ascorbate)
Calcium .................................................... 75 mg
(as Ester-C? calcium ascorbate)
Bioflavonoids .............................................. 50 mg
Pycnogenol? ................................................ 3 mg
Rutin ...................................................... 50 mg
Proprietary Blend .......................................... 6 mg
(Quercetin, Echinacea [root] and Beta-Carotene)
Ester-C is a licensed trademark of Zila Nutraceuticals,Inc. Manufactured under U.S. Patent Nos.4,822,816 and 5,070,085 and corresponding foreign patents. Other patents pending.
Pycnogenol? is a registred trademark of Horphag Research Ltd. Use of this product is protected by one or more of U.S. patents #4,698,360/#5,720,956/6,372,266 and other international patents
SUGGESTED USE
1 to 2 capsules daily or as directed by healthcare professional.
SIDE EFFECTS
No adverse effects have been reported.
STORAGE
Store in a cool, dry place, away from direct light. Keep out of reach of children.
REFERENCES
Barab?s J, Nagy E, Degrell I. Ascorbic acid in cerebrospinal fluid--A possible protection against free radicals in the brain. Arch Gerontol Geriatr 1995;21:43-48.
Bendich A, Langseth L. The health effects of vitamin C supplementation: A review. J Am Coll Nutr 1995;14:124-136.
Berkarda B, Koyuncu H, Soybir G, Baykut F. Inhibitory effect of
Hesperidin on tumour initiation and promotion in mouse skin. Res Exp Med (Berl) 1998 Aug;198(2):93-9.
Beyer RE. The role of ascorbate in antioxidant protection of biomembranes: Interaction with vitamin E and coenzyme Q. J Bioenerg Biomembr 1994;26:349-358.
Bush MJ, Verlangieri AJ. An acute study on the relative gastro-intestinal absorption of a novel form of calcium ascorbate. Res Commun Chem Pathol Pharmacol 1987;57:137-140.
Cunningham JJ, Mearkle PL, Brown RG. Vitamin C: An aldose reductase inhibitor that normalizes erythrocyte sorbitol in insulin-dependent diabetes mellitus. J Am Coll Nutr 1994;13:344-350.
Edwards DJ, Bernier SM. Naringin and naringenin are not the primary CYP3A inhibitors in grapefruit juice. Life Sci 1996;59(13):1025-30.
Eriksson J, Kohvakka A. Magnesium and ascorbic acid supplementation in diabetes mellitus. Ann Nutr Metab 1995;39:217-223.
Faruque MO, Khan MR, Rahman M, Ahmed F. Relationship between smoking and antioxidant nutrient status. Br J Nutr 1995;73:625-632.
Franke AA, Cooney RV, Custer LJ, et al. Inhibition of neoplastic transformation and bioavailability of dietary flavonoid agents. Adv Exp Med Biol 1998;439:237-48.
Frei B. Reactive oxygen species and antioxidant vitamins: Mechanisms of action. Am J Med 1994;97 Suppl. 3A:5S-13S.
Galati EM, Trovato A, Kirjavainen S, Forestieri AM. Biological effects of hesperidin,
a Citrus flavonoid. (Note III): antihypertensive and diuretic activity in rat. Farmaco 1996 Mar;51(3):219-21.
Gale CR, Martyn CN, Winter PD, Cooper C. Vitamin C and risk of death from stroke and coronary heart disease in cohort of elderly people. BMJ 1995;310:1563-1566.
Gerster H. Antioxidant vitamins in cataract prevention. Z Ernahrungswiss 1989;28:56-75.
Ghosh SK, Ekpo EB, Shah IU, Girling AJ, Jenkins C, Sinclair AJ. A double-blind, placebo-controlled parallel trial of vitamin C treatment in elderly patients with hypertension. Gerontology 1994;40:268-272.
Green MHL, Lowe JE, Waugh APW, Aldridge KE, Cole J, Arlett CF. Effect of diet and vitamin C on DNA strand breakage in freshly-isolated human white blood cells. Mutat Res DNAging Genet Instability Aging 1994;316:91-102.
Grimm T, Schafer A, Hogger P. Antioxidant activity and inhibition of matrix metalloproteinases by metabolites of maritime pine bark extract (pycnogenol). Free Radic Biol Med. 2004 Mar 15;36(6):811-22.
Gruenwald J, Graubaum HJ, Busch R, Bentley C.
Safety and tolerance of ester-C compared with regular ascorbic acid. Adv Ther. 2006 Jan-Feb;23(1):171-8.
Guilhou JJ, Fevrier F, Debure C, et al. Benefit of a 2-month treatment with a micronized, purified flavonoidic fraction on venous ulcer healing. A randomized, double-blind, controlled versus placebo trial. Int J Microcirc Clin Exp 1997;17 Suppl 1:21-6.
Lehr H-A, Frei B, Arfors K-E. Vitamin C prevents cigarette smoke-induced leukocyte aggregation and adhesion to endothelium in vivo. Proc Natl Acad Sci USA 1994;91:7688-7692.
Miyake Y, Yamamoto K, Tsujihara N, Osawa T. Protective effects of lemon flavonoids on oxidative stress in diabetic rats. Lipids 1998 Jul;33(7):689-95.
Mukhopadhyay CK, Chatterjee IB. Free metal ion-independent oxidative damage of collagen. Protection by ascorbic acid. J Biol Chem 1994;269:30200-30205.
Paolisso G, Balbi V, Volpe C, et al. Metabolic benefits deriving from chronic vitamin C supplementation in aged non-insulin dependent diabetics. J Am Coll Nutr 1995;14:387-392.
Sauberlich HE. Pharmacology of vitamin C. Annu Rev Nutr 1994;14:371-391.
Seddon JM, Ajani UA, Sperduto RD, et al. Dietary carotenoids, vitamins A, C, and E, and advanced age- related macular degeneration. Eye Disease Case-Control Study Group. JAMA 1994;272:1413-1420.
These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
Manufactured by
Douglas Laboratories
600 Boyce Road
Pittsburgh, PA 15205
800-245-4440
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